Wisdom Wednesday: The Pancreas

The pancreas is the last organ in the endocrine system that we evaluate. We began with the endocrine system as a whole – adrenal, pineal/pituitary, thyroid, and reproduction. Then we looked at hidden adrenal issues. Last week we reviewed liver function; now finally, the pancreas.

The head of the pancreas secretes digestive enzymes. Digestion will be discussed next week. The tail of the pancreas secretes insulin and other hormones. Insulin binds to glucose in the blood stream and facilitates entry to most cells of the body.

Over the course of our lives, most of us become insulin resistant. Excess refined carbohydrates and just eating too much in general tax the system. Insulin receptors in the cells of the body become less responsive to insulin so the pancreas must produce ever increasing quantities of insulin to force sugar into the cells. This is early stage Type II Diabetes.

Eventually, the pancreas just wears out, insulin production falls and the body becomes dependent on insulin injections to maintain some semblance of glucose control.

There are four tissues that do not require insulin to absorb glucose – the small capillaries, the kidneys, the nervous system and the eyes. These tissues are saturated with excess glucose for years prior to the diagnosis of diabetes. The result is progressive degeneration of these tissues resulting in neuropathy, blindness, amputation of the lower extremities, kidney failure, and ultimately death.

It is estimated that by the year 2050, 50% of the US population will be diabetic. Diabetes is an epidemic that is preventable and often reversible just by making good choices in diet and exercise.

When evaluating the pancreas, we correlate function with the remainder of the endocrine system. Sometimes pancreas dysfunction is secondary to an adrenal issue or a thyroid problem. However, most commonly, the problem begins with general inflammation.

When the body is inflamed, from just about any cause, it produces arachidonic acid. This most frequently results in the production of prostaglandins (PG2), primarily from the liver. (Please review my first Wednesday Wisdom blog on QA evaluation, “Inflammation – part 1”, posted on March 19, 2014) Adequate intake of omega 3 and omega 6 fatty acids should produce PG3 and PG1 respectively, which counterbalance the inflammation from PG2. However, early on in insulin resistance, the conversion of healthy omega 6 fatty acids from the diet is shunted into the arachidonic acid pathway creating more inflammation rather than less.

Supplementation with sesame seed oil prevents this shunting and restores the omega 6 to PG1 pathway. This simple change in body chemistry often dramatically improves glucose metabolism, even in drug dependent diabetics.

In resistant cases, the herb Gymnema can be most effective. Gymnema actually helps restore the beta cells of the pancreas that secrete insulin. In Ayurvedic medicine, Gymnema means “sugar destroyer”. For thousands of years, it has been used to eliminate the sickly sweet smell of urine produced when diabetics spill glucose into the urine in an attempt to reduce blood levels.

THE BOTTOM LINE:
If you are not yet diabetic, the odds are quite good that you will become one. Have your glycohemoglobin A1c checked yearly. It will detect problems in glucose metabolism years before the fasting glucose is out of control and the diagnosis of diabetes is given. Maintain a regime of regular exercise and reduce the refined carbohydrates in your diet.

If you have a blood sugar issue, no matter how advanced, consult with a qualified nutritionist. The damage begins long before you are aware you have a problem. However, it can be reversed with proper guidance.

Wisdom Wednesday: Inflammation – Part 4

Insulin, the hormone produced by the pancreas to escort glucose into the cells of the body, can stimulate inflammation. It is the most insidious inflammatory pathway and very difficult to reverse.

Most cells in the body require adequate insulin in the blood stream to facilitate glucose absorption. However, a majority of Americans are now insulin resistant. They eat too much and too much of the wrong foods – refined carbohydrates. As the pancreas increases the output of insulin to control glucose levels, the body slowly becomes insulin resistant. This occurs long before the eventual diagnosis of Type II diabetes. It is estimated that by the year 2050, over half of all Americans will be diabetic.

Today, many of these young Americans are already insulin resistant and pre-diabetic. The systemic inflammation caused by excess insulin production is evidenced by our inability to process omega 6 fatty acids, like olive oil.

Most nutritionists recommend against supplementing omega 6 fatty acids. They claim that the omegas 6’s are abundant in our diet and that they can be pro-inflammatory. Although both of those claims are true, I disagree with their recommendations. First, the omega 6 fatty acids in our diet need to be converted to GLA (gamma linolenic acid) and many people can not make that conversion. Secondly, it’s only the people who are insulin resistant that take healthy omega 6 fatty acids and convert them to inflammatory compounds. I recommend fixing the chemistry rather than denying the body an essential fatty acid. Essential means just that, your body can not make it, it is essential to the diet.

The key, of course, is cleaning up the diet, reversing all the factors associated with metabolic syndrome – central obesity, high blood pressure, low thyroid function, high serum lipids, and insulin resistance. In the meantime, the addition of sesame seed oil, and possibly GLA, to the diet will support healthy utilization of omega 6 fatty acids and effectively block the conversion to inflammatory compounds.

I have seen uncontrolled type II diabetics, on multiple medications, cut their medication by 75% with the simple addition of sesame seed oil and GLA, while reducing their blood sugar levels from over 250mg/dL to 85mg/dL in less than 3 weeks. Simultaneously, their inflammatory complaints – IBS, musculoskeletal pain, headaches, etc. also improve markedly.

In my office, as soon as I see impaired chemistry on the omega 6 fatty acids, I suspect insulin resistance as the cause. Fortunately, the glycohemoglobin A1c is a simple blood test that tells us what your blood sugar has been averaging for the past 60 days. I mention this test often in my blogs and I advise you to have this test run annually.

THE BOTTOM LINE:
Diabetes is epidemic in our county and is not only preventable, but often time’s reversible. The vast majority of pre-diabetics are undiagnosed. The odds are at least half of you reading this blog are pre-diabetic. Get an A1c performed. If you have any of the characteristics of metabolic syndrome and you suffer from inflammation, chances are your pain is being driven by insulin.