Proton pump inhibitors (PPIs) seem to be linked with an increased risk of chronic kidney disease, two new studies suggest.
Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach.
While the current studies have shown as association between these drugs and the development of chronic kidney disease, they did not prove cause-and-effect relationship.
Still, the lead author of one of the studies believes, “It is very reasonable to assume that PPIs themselves can cause chronic kidney disease,” said Dr. Pradeep Arora, a nephrologist and associate professor at the SUNY Buffalo School of Medicine and Biomedical Science in Buffalo, N.Y.
“Patients should only use PPIs for [U.S. FDA] approved indications, and not to treat simple heartburn or [indigestion],” he cautioned.
Chronic kidney disease is increasing in the United States, with more than 20 million Americans now suffering with it, according to the American Society of Nephrology. This occurs when a person’s kidneys become damaged and can’t filer blood as they should. Diabetes and high blood pressure are two common risk factors for kidney disease, the society said.
Arora’s study involved more than 24,000 patient who developed chronic kidney disease between 2001 and 2008.
One out of the four of the kidney patients had been previously treated using a PPI. People taking a PPI also had nearly twice the risk of dying prematurely, the researchers found.
In the second study, researchers were led by Dr. Benjamin Lazarus from Royal Brisbane and Women’s Hospital in Australia, and Johns Hopkins University in Baltimore. They followed more than 10,000 adults with normal kidney function form 1996 to 2011.
Showing posts with label Prevacid. Show all posts
Showing posts with label Prevacid. Show all posts
Friday, November 6, 2015
Sunday, December 15, 2013
Acid-Suppressing Drugs Linked to Vitamin B12 Deficiency
A new study published in the Journal of the American Medical Association reports that people who use certain acid-suppressing drugs for two years or longer are at increased risk of vitamin B12 deficiency.
December 10, 2013
This can lead to anemia, neuropathy, depression, fatigue, or dementia. The drugs are proton-pump inhibitors, or P.P.I.’s and histamine 2 receptor antagonists. They are available by prescription and over the counter under names like Prevacid, Prilosec and Nexium. Nearly 157 million prescriptions were written for P.P.I.’s in 2012.
“People who are taking this medications are more likely than the average person to be vitamin B12 deficient, and it’s a potentially serious problem,” said Dr. Douglas Corley, senior author of the study. Of note, the study was funded by Pfizer, which makes a P.P.I. called Protonix.
Patients who took P.P.I.’s for more than two years were 65 percent more likely to have a vitamin B12 deficiency, the researchers found. Higher doses of P.P.I’s were more strongly associated with the vitamin deficiency, as well.
MY TAKE:
These drugs prevent the stomach from manufacturing hydrochloric acid (HCl) thus reducing the symptoms of acid reflux. However, HCl is the first major step in digestion. It breaks down protein, separates calcium ions from their substrate, and prepares vitamin B12 for assimilation in the small intestine. It is also the triggering mechanism for the gallbladder to release bile and the second major step in digestion once the food bolus enters the small intestine. We now know (and have predicted) that P.P.I.’s cause osteoporosis, anemia, dysbiosis, and chronic Candida infections. Clinically, I see frequent gallbladder congestion associated as well.
Unfortunately, if you burp once in a while, that seems to be enough criteria to prescribe one of these drugs. A simple test of the pH of the stomach will detect over-acid production, but the testing is seldom run. A lack of HCl production will also cause acid reflux, as the food putrefies, producing organic acids in the stomach. It is estimated that a lack of HCl accounts for 50 percent of the cases of acid reflux.
The cause in most cases is poor diet. Food sensitivities, over eating, excessive fat and sometimes even poor food combining are real issues. When a patient obtains relieve from the drug, they continue their poor eating habits further compromising general health.
THE BOTTOM LINE:
Avoid these P.P.I,’s like the plague! Your symptoms are warning signals that the digestive tract is in trouble. Have your diet evaluated. Often just reducing caloric intake will dramatically improve or eliminate symptoms.
December 10, 2013
This can lead to anemia, neuropathy, depression, fatigue, or dementia. The drugs are proton-pump inhibitors, or P.P.I.’s and histamine 2 receptor antagonists. They are available by prescription and over the counter under names like Prevacid, Prilosec and Nexium. Nearly 157 million prescriptions were written for P.P.I.’s in 2012.
“People who are taking this medications are more likely than the average person to be vitamin B12 deficient, and it’s a potentially serious problem,” said Dr. Douglas Corley, senior author of the study. Of note, the study was funded by Pfizer, which makes a P.P.I. called Protonix.
Patients who took P.P.I.’s for more than two years were 65 percent more likely to have a vitamin B12 deficiency, the researchers found. Higher doses of P.P.I’s were more strongly associated with the vitamin deficiency, as well.
MY TAKE:
These drugs prevent the stomach from manufacturing hydrochloric acid (HCl) thus reducing the symptoms of acid reflux. However, HCl is the first major step in digestion. It breaks down protein, separates calcium ions from their substrate, and prepares vitamin B12 for assimilation in the small intestine. It is also the triggering mechanism for the gallbladder to release bile and the second major step in digestion once the food bolus enters the small intestine. We now know (and have predicted) that P.P.I.’s cause osteoporosis, anemia, dysbiosis, and chronic Candida infections. Clinically, I see frequent gallbladder congestion associated as well.
Unfortunately, if you burp once in a while, that seems to be enough criteria to prescribe one of these drugs. A simple test of the pH of the stomach will detect over-acid production, but the testing is seldom run. A lack of HCl production will also cause acid reflux, as the food putrefies, producing organic acids in the stomach. It is estimated that a lack of HCl accounts for 50 percent of the cases of acid reflux.
The cause in most cases is poor diet. Food sensitivities, over eating, excessive fat and sometimes even poor food combining are real issues. When a patient obtains relieve from the drug, they continue their poor eating habits further compromising general health.
THE BOTTOM LINE:
Avoid these P.P.I,’s like the plague! Your symptoms are warning signals that the digestive tract is in trouble. Have your diet evaluated. Often just reducing caloric intake will dramatically improve or eliminate symptoms.
Subscribe to:
Posts (Atom)