Wednesday, August 29, 2018

Wisdom Wednesday: Pesticide Linked to Autism


Autism is a complex neurodevelopmental disorder with a largely unknown etiology. To date, few studies have investigated prenatal exposure to toxins and risk of autism by using maternal biomarkers of exposure. Persistent organic pollutants are lipophilic halogenated organic compounds and include the insecticide dichlorodiphenyltrichloroethane (DDT), as well as its metabolite p,p′-dichlorodiphenyl dichloroethylene (p,p′-DDE), and polychlorinated biphenyls (PCBs). The objective of this study was to test whether elevated maternal levels of persistent organic pollutants are associated with autism among offspring.

The investigation was derived from the Finnish Prenatal Study of Autism, a national birth cohort study based on a nested case-control design. Cases of autism among children born between 1987 and 2005 were ascertained by national registry linkages. In cases of childhood autism and matched control subjects (778 matched case-control pairs), maternal serum specimens from early pregnancy were assayed for levels of p,p′-DDE and total levels of PCBs.

The odds of autism among offspring were significantly increased with maternal p,p′-DDE levels that were in the highest 75th percentile, with adjustment for maternal age, parity, and history of psychiatric disorders (odds ratio=1.32, 95% CI=1.02, 1.71). The odds of autism with intellectual disability were increased by greater than twofold with maternal p,p′-DDE levels above this threshold (odds ratio=2.21, 95% CI=1.32, 3.69). There was no association between total levels of maternal PCBs and autism.

These findings provide the first biomarker-based evidence that maternal exposure to insecticides is associated with autism among offspring. Although further research is necessary to replicate this finding, this study has implications for the prevention of autism and may provide a better understanding of its pathogenesis.

My Take:
Although DDT was banned in the United States in 1972, it still remains in our environment, along with all its’ metabolites. It is still used in many parts of the world and limited uses in the US continue under “public health exception, for emergency agricultural use.” This continued use is not well publicized.

The half-life for DDT is 2-15 years with 97% of it degraded after 5 half-lives. It stores in the fatty tissues of our bodies and has been linked with Alzheimer’s disease, MS and other chronic degenerative conditions.

Clinically, I find reflex testing for both DDT and Round Up quite often. Both of these toxic chemicals are in all of us. It appears that DDT predominates in my older patients while Round Up shows up in younger patients. The real question is do these toxins need to be removed from the body? More and more, the answer is yes, although it often is not the first priority.

Bottom Line:
Autism is multifactorial but I strongly suspect that environmental toxins are a major factor in the dramatic increase in the rate of autism worldwide.

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