Monday, September 24, 2018

Breast Milk Provides Food Allergy Protection

Replicating the nourishment found in mother’s milk has been a challenge, especially since science continues to reveal its complex composition. Previous research indicates breastfed children have a lower risk of certain medical conditions, such as wheezing, infections, asthma and obesity. Identifying specific components that influence immunity is key to identifying a potential for therapeutic interventions.

A recent study hypothesized that “sensitization resulting from the composition of complex sugars in breast milk [could possibly] prevent future food allergies,” and this hypothesis was verified in 1-year-old infants (N=421). Human milk oligosaccharides (HMOs) are structurally complicated sugar molecules unique to breast milk. Classified as “the third most abundant solid component in human milk after lactose and fat,” they are indigestible, but play a key prebiotic role and help develop the infant’s gut microbiota.

This team found that the overall HMO composition appeared to play a role in food sensitization, however, “no individual HMO was as yet associated with food sensitization.”  Even though the composition of HMOs in breast milk varies depending on the lactation stage, gestational age, maternal health, ethnicity, geographic location and whether or not the mother is breastfeeding exclusively, a beneficial HMO profile was associated with a lower rate of food sensitization in children at one year.

Friday, September 21, 2018

Can eating this type of sugar prevent weight gain?

Mannose, a type of sugar, can greatly affect metabolism, weight gain, and the composition of gut bacteria in rodents. This result may lead to new treatments and prevention strategies for both obesity and weight gain.

More and more studies are unraveling the multi-layered relationship between our gut microbiome and weight gain. A few years ago, a twin study that Medical News Today reported on found that genes influence the bacteria that live in our gut, which, in turn, influence whether we gain weight or not. Another paper proposed that our diets influence our guts’ “power” to decide how much weight we gain.

Belly fat – the most harmful type of fat – in particular is known to be driven by our gut bacteria, but the food that we eat, this study suggested, plays a more important role in these weight-regulating gut processes than genes. New research brings further nuance to this latter idea. Specifically, a new study looks at how the intake of mannose, a type of sugar, affects the gut bacteria and weight gain in mice.

Hudson Freeze, Ph.D., director of the Human Genetics Program at the Sanford Burnham Prebys Medical Discovery Institute in San Diego, CA, and colleagues observed the effects of mannose on weight gain while they were studying its’ therapeutic effects on CDG (congenital glycosylation). Then the team decided to investigate the effects of mannose further.

The study revealed that mice that were fed a high-fat diet plus mannose were leaner, had less fat in their livers, were more tolerant to glucose, and had overall higher levels of fitness than mice that had the mannose-free diet.

Wednesday, September 19, 2018

Wisdom Wednesday: What allows C. difficile to survive so well in the gut?

Clostridium difficile is a particularly hardy type of bacteria, which is very difficult to treat. It often affects people during a hospital stay – especially if they have taken antibiotics. Why is it this resilient, and does knowing this lead to better treatments?

According to some experts, Clostridium difficile infections are ever on the rise and becoming increasingly difficult to treat. This means that researchers need to find new and better ways of targeting this stubborn bacterium. Among other symptoms, C. difficile can cause diarrhea, which can range from mild to extremely severe. In the most extreme cases, the infection can even lead to death.

Recently, a team from the London School of Hygiene and Tropical Medicine in the United Kingdom made a new and important discovery: C. difficile releases a special compound that allows it to gain ground over gut bacteria and to establish a strong presence in the gut environment. This findings are now published in the journal PLOS Pathogens.

C. difficile infections often appear after a person has followed a treatment with antibiotics, because these drugs work by essentially killing bacteria. Unfortunately, antibiotic do not only destroy the bacteria that cause harm.

Antibiotics also disrupt the balance of the gut microbiota, which contains many types of bacteria that are harmless and promote or sustain the health of the intestines. When this happens, C. difficile sometimes takes hold – and fighting it is often very complicated.

For the first time, researcher Lisa Dawson and team found that the release of para-cresol by C. difficile affects the growth of many microorganisms in the gut and allows it to prevail over other bacteria.

Monday, September 17, 2018

LDL More Than 160 Tied to Increased Mortality in Low-Risk Patients

Patients deemed at low-risk for cardiovascular disease (CVD) but with LDL levels above 160 face increased mortality risks over the long term, a Circulation study suggests.

Over 36,000 adults in Texas (median age, 42) with an estimated 10-year risk for atherosclerotic CVD events below 7.5% had their lipid levels measured and were followed for a median of 27 years. During that time, nearly 1100 CVD deaths and 600 coronary heart disease (CHD) deaths occurred.

After multivariable adjustment, participants with LDL levels of 160–189 mg dL had a 70% increased risk for CVD mortality and more than twice the risk for CHD mortality, relative to those with LDL below 100 mg dL. Increasing levels of non-HDL cholesterol were also associated with higher mortality risks.

The researchers note that 2013 cholesterol guidelines recommend statins for low-risk patients when LDL reaches 190 mg dL, with a class IIb recommendation for considering treatment at 160 mg dL. They say their current findings "suggest a stronger consideration of using the LDL-C greater than 160 mg dL cutoff."

My Take:
The medical norms for LDL are less than 130 mg dl. However, many labs list the medical norm as less than 100 mg dl as that is the goal of statin drug therapy. Many physicians like to drive the LDL level less than 60 mg dl, although the research indicates no additional benefit in cardiovascular risk is associated with this goal.

Friday, September 14, 2018

Nutrition and Functional Neurology: Partners in Holistic Patient Care

Sweeping through models of chiropractic care, functional neurology is transitioning away from the limited concept of vertebral fixations to embracing the concept of neural tone, championed by the very originator of chiropractic – D.D. Palmer. Indeed, the updated definition of subluxation put forth by the Council for Chiropractic Practice in 2013 plainly states that subluxation is “a neurological imbalance or distortion in the body associated with adverse physiological responses and/or structural changes which may become persistent or progressive.” Following this line of reasoning, functional neurology opens the discussion to a range of causes of the neurological imbalances, including (i) inflammation, (ii) nutritional problems, (iii) hormonal imbalances, (iv) emotional stress, and (v) structural derangements that dominated earlier models of chiropractic interventions.

The positive aspect of functional neurology is its reorganization of nerve cells, making possible the restoration or bypass of connections that have become disrupted or damaged. A perfect example would be performing exercises to recover from [a] stroke. The negative aspect of functional neurology, however, is that if a neuronal pathway is not fired, synaptic connections may become inactive with the loss or inactivation of neurotransmitters and receptors, as exemplified by the risk of cognitive decline in the elderly and the undertaking of exercise to counteract that effect. Both of these transformations of nervous system activity have become known as neuroplasticity, not limited to neural injury or recovery but also including the remodeling of dendrites, synapse turnover, long-term potentiation, and neurogenesis. One striking example out of many demonstrating the phenomenon of neuroplasticity was offered by an observational study of London cab drivers, in which there was a redistribution of gray matter in their brains as they became familiar with the city’s layout.

Wednesday, September 12, 2018

Wisdom Wednesday: The Dirty Dozen

Every year, the Environmental Working Group (EWG) releases the “Dirty Dozen” – a list of the 12 non-organic fruits and vegetables highest in pesticide residues.

Pesticides are substances commonly used in agriculture to protect drops from damage caused by insects, weed pressure and diseases. To compile the Dirty Dozen list, the EWG analyzes over 38,000 samples taken by the USDA and FDA to single out the worst offenders.

While the EWG claims that this list can help consumers avoid unnecessary pesticide exposure, some experts – including food scientists – argue that the list is scaring the public away from consuming healthy foods.

Pesticides are tightly regulated by the USDA, and recent reports indicate that pesticide levels found on 99.5% of conventional produce are well below recommendations set by the EPA. The USDA Pesticide Data Program ensures that the U.S. food supply “is one of the safest in the world,” due to rigorous testing methods.

However, many experts argue that continuous exposure to pesticides – even in small doses – can build up in your body overtime and lead to chronic health conditions.

Additionally, there is concern that the safe limits set by regulatory agencies don’t take into consideration the health risks involved with consuming more than one pesticide at a time.

Monday, September 10, 2018

The Man Who Sold America On Vitamin D – And Profited in the Process

Dr. Michael Holick’s enthusiasm for vitamin D can be fairly described as extreme. The Boston University endocrinologist, who perhaps more than anyone else is responsible for creating a billion-dollar vitamin D sales and testing juggernaut, elevates his low levels of the stuff with supplements and fortified milk. When he bikes outdoors, he won’t put sunscreen on his limbs. He has written book-length odes to vitamin D, and has warned in multiple scholarly articles about a “vitamin D deficiency pandemic” that explains disease and suboptimal health across the world.

His fixation is so intense that it extends to the dinosaurs. What if the real problem with that asteroid 65 million years ago wasn’t a lack of food, but the weak bones that follow a lack of sunlight? “I sometimes wonder,” Holick has written, “did the dinosaurs die of rickets and osteomalacia?”

Holick’s role in drafting national vitamin D guidelines, and the embrace of his message by mainstream doctors and wellness gurus alike, have helped push supplement sales to $936 million in 2017. That’s a ninefold increase over the previous decade. Lab tests for vitamin D deficiency have spiked, too. Doctors ordered more than 10 million for Medicare patients in 2016, up 547% since 2007, at a cost of $365 million. About 1 in 4 adults 60 and older now take vitamin D supplements.

But few of the Americans swept up in the vitamin D craze are likely aware that the industry has sent a lot of money Holick’s way. A Kaiser Health News investigation found that he has used his prominent position in the medical community to promote practices that financially benefit corporations that have given him hundreds of thousands of dollars – including drugmakers, the indoor-tanning industry and one of the country’s largest commercial labs.

In an interview, Holick acknowledged he has worked as a consultant to Quest Diagnostics, which performs vitamin D tests since 1979. Holick, 72, said that industry funding “doesn’t influence me in terms of talking about the health benefits of vitamin D.”